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FLASH GENE

Symbol

ASB4

contributors: mct/npt - updated : 05-05-2009

HGNC name	ankyrin repeat and SOCS box-containing 4
HGNC id	16009

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

Location	7q21-q22      Physical location : 95.115.283 - 95.167.069
Synonym name	ASB-4 protein
Synonym symbol(s)	ASB-4, MGC142039, MGC142041

DNA

TYPE	functioning gene
STRUCTURE	51.80 kb     5 Exon(s)

10 Kb 5' upstream gene genomic sequence study

MAPPING

cloned

Y

linked

N

status

provisional

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed variant 1 - - 1281 48 426 - - variant 2 - - 1494 39 349 - -

EXPRESSION

Type

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Reproductive male system testis

cell lineage

cell lines

fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains	nine N terminal ankyrin repeats
	a conserved C terminal SOCS motif

HOMOLOGY

interspecies

ortholog to murine Asb4

Homologene

FAMILY

ankyrin repeat and SOCS box-containing (ASB) family of proteins

CATEGORY

regulatory , signaling

SUBCELLULAR LOCALIZATION	intracellular
	intracellular,cytoplasm,cytosolic

basic FUNCTION

inhibits cytokine signaling

CELLULAR PROCESS	protein, post translation
	protein, degradation
	protein, ubiquitin dependent proteolysis

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

signal transduction

intracellular signaling cascade

a component

INTERACTION

DNA

RNA

small molecule

protein	JAK kinases
	activated cytokine receptors
	elonguin B/C complex
	interacting with GPS1 to inhibits JNK activity (Li 2007)

cell & other

REGULATION

induced by

cytokines

ASSOCIATED DISORDERS

ANIMAL & CELL MODELS