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FLASH GENE
Symbol GNG4 contributors: mct - updated : 28-03-2017
HGNC name guanine nucleotide binding protein (G protein), gamma 4
HGNC id 4407
EXPRESSION
Type
   expressed in (based on citations)
organ(s)
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Muscularstriatumcardiac  
Muscularstriatumskeletal  
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • GGL domain
    • secondary structure alpha, beta, gamma subunit
    HOMOLOGY
    interspecies homolog to gng4
    Homologene
    FAMILY
  • G protein gamma family
    • CATEGORY signaling , receptor membrane G
    SUBCELLULAR LOCALIZATION extracellular
        plasma membrane
    basic FUNCTION
  • gamma subunit of the G protein complex, having the potential to negatively regulate signaling downstream of oncogenic GPCRs
  • GNG4 indeed is a potential tumor suppressor in glioblastoma (GBM)
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • C terminus of GNG4 showed strong interaction with KCNK2, whereas N terminus did not
  • GNG4 is an inhibitor of CXCL12/CXCR4-dependent signaling
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --low  
    by hypermethylation in mesenchymal glioblastoma
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS