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FLASH GENE

Symbol

GNG4

contributors: mct - updated : 28-03-2017

HGNC name	guanine nucleotide binding protein (G protein), gamma 4
HGNC id	4407

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

DNA

TYPE	functioning gene
STRUCTURE	103.07 kb     4 Exon(s)

Genomic sequence alignment details
10 Kb 5' upstream gene genomic sequence study

MAPPING

cloned

Y

linked

N

status

provisional

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_001098721 4 - 4997 NP_001092191 8.4 75 - 1995 7665596 NM_001098722 4 - 5123 NM_001098722 8.4 75 - 1995 7665596 NM_004485 3 - 4885 NP_004476 8.4 75 - 1995 7665596

EXPRESSION

Type

expressed in	(based on citations)
organ(s)

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Muscular striatum cardiac     Muscular striatum skeletal

cell lineage

cell lines

fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains

GGL domain

secondary structure

alpha, beta, gamma subunit

HOMOLOGY

interspecies

homolog to gng4

Homologene

FAMILY

G protein gamma family

CATEGORY

signaling , receptor membrane G

SUBCELLULAR LOCALIZATION	extracellular
	plasma membrane

basic FUNCTION	gamma subunit of the G protein complex, having the potential to negatively regulate signaling downstream of oncogenic GPCRs
	GNG4 indeed is a potential tumor suppressor in glioblastoma (GBM)

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component

INTERACTION

DNA

RNA

small molecule

protein	C terminus of GNG4 showed strong interaction with KCNK2, whereas N terminus did not
	GNG4 is an inhibitor of CXCL12/CXCR4-dependent signaling

cell & other

REGULATION

ASSOCIATED DISORDERS

corresponding disease(s)

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function tumoral     --low   by hypermethylation in mesenchymal glioblastoma

Susceptibility

Variant & Polymorphism

Candidate gene

Marker

Therapy target

ANIMAL & CELL MODELS