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Symbol GNG4 contributors: mct - updated : 28-03-2017
HGNC name guanine nucleotide binding protein (G protein), gamma 4
HGNC id 4407
Location 1q42.3      Physical location : 235.710.986 - 235.814.054
Synonym name
  • guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-4
  • guanine nucleotide binding protein 4
    • Synonym symbol(s) GNGT4, DKFZp547K1018, FLJ23803, FLJ34187, IG, SG
    DNA
    TYPE functioning gene
    STRUCTURE 103.07 kb     4 Exon(s)
    Genomic sequence alignment details
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    4 - 4997 8.4 75 - 1995 7665596
    4 - 5123 8.4 75 - 1995 7665596
    3 - 4885 8.4 75 - 1995 7665596
    EXPRESSION
    Type
       expressed in (based on citations)
    organ(s)
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Muscularstriatumcardiac  
    Muscularstriatumskeletal  
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • GGL domain
    • secondary structure alpha, beta, gamma subunit
    HOMOLOGY
    interspecies homolog to gng4
    Homologene
    FAMILY
  • G protein gamma family
    • CATEGORY signaling , receptor membrane G
    SUBCELLULAR LOCALIZATION extracellular
        plasma membrane
    basic FUNCTION
  • gamma subunit of the G protein complex, having the potential to negatively regulate signaling downstream of oncogenic GPCRs
  • GNG4 indeed is a potential tumor suppressor in glioblastoma (GBM)
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • C terminus of GNG4 showed strong interaction with KCNK2, whereas N terminus did not
  • GNG4 is an inhibitor of CXCL12/CXCR4-dependent signaling
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --low  
    by hypermethylation in mesenchymal glioblastoma
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS