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FLASH GENE
Symbol SYT10 contributors: mct - updated : 26-11-2011
HGNC name synaptotagmin X
HGNC id 19266
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a short N-terminal intravesicular sequence
  • a single transmembrane region, a linker sequence
  • a linker sequence
  • two protein kinase C homologous repeats (Ca2+ binding domains C2)
  • a conserved WHXL motif in the C terminus
    • mono polymer homomer , heteromer , complex
    HOMOLOGY
    interspecies ortholog to murine Syt10
    Homologene
    FAMILY synaptotagmin family
    CATEGORY structural protein
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm,cytosolic,vesicle
    text
  • SYT10 colocalized with IGF1 in somatodendritic vesicles of olfactory bulb neurons
    • basic FUNCTION
  • SYT3, SYT5, SYT6, and SYT10 exhibit similar Ca2+-dependent phospholipid- and SNARE-binding properties as SYT1, although with a higher apparent Ca2+-affinity
  • functions as the Ca2+-sensor that triggers IGF1 exocytosis in the olfactory bulb neurons
  • controls a previously unrecognized pathway of Ca2+-dependent exocytosis that is spatially and temporally distinct from Ca2+-dependent synaptic vesicle exocytosis controlled by SYT1
  • acts as a Ca2+-sensor to maintain the normal size and arborization of olfactory bulb neurons, with a function that is unique to this synaptotagmin isoform and not shared by other, closely related synaptotagmins
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • SYT10 belongs to a group of Ca2+-binding synaptotagmins that includes SYT3, SYT5, and SYT6, and that differs from the group containing SYT1
    • INTERACTION
    DNA
    RNA
    small molecule metal binding,
    calcium Ca2+
    protein
  • vesicular Ca2+-sensor for IGF1 containing vesicles that mediates rapid activity-dependent secretion of IGF1
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS