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FLASH GENE
Symbol SYT10 contributors: mct - updated : 26-11-2011
HGNC name synaptotagmin X
HGNC id 19266
Location 12p11.1      Physical location : 33.528.347 - 33.592.754
Genatlas name synaptotagmin 10
DNA
TYPE functioning gene
STRUCTURE 64.40 kb     7 Exon(s)
MAPPING cloned Y linked N status provisional
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
7 - 3286 - 523 - 2011 21496647
EXPRESSION
Type
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Olfactory (smell)olfactory bulb     Homo sapiens
cells
SystemCellPubmedSpeciesStageRna symbol
Nervousneuron Homo sapiens
Olfactoryepithelial cell Homo sapiens
Olfactoryolfactory receptor Homo sapiens
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a short N-terminal intravesicular sequence
  • a single transmembrane region, a linker sequence
  • a linker sequence
  • two protein kinase C homologous repeats (Ca2+ binding domains C2)
  • a conserved WHXL motif in the C terminus
  • mono polymer homomer , heteromer , complex
    HOMOLOGY
    interspecies ortholog to murine Syt10
    Homologene
    FAMILY synaptotagmin family
    CATEGORY structural protein
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm,cytosolic,vesicle
    text
  • SYT10 colocalized with IGF1 in somatodendritic vesicles of olfactory bulb neurons
  • basic FUNCTION
  • SYT3, SYT5, SYT6, and SYT10 exhibit similar Ca2+-dependent phospholipid- and SNARE-binding properties as SYT1, although with a higher apparent Ca2+-affinity
  • functions as the Ca2+-sensor that triggers IGF1 exocytosis in the olfactory bulb neurons
  • controls a previously unrecognized pathway of Ca2+-dependent exocytosis that is spatially and temporally distinct from Ca2+-dependent synaptic vesicle exocytosis controlled by SYT1
  • acts as a Ca2+-sensor to maintain the normal size and arborization of olfactory bulb neurons, with a function that is unique to this synaptotagmin isoform and not shared by other, closely related synaptotagmins
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • SYT10 belongs to a group of Ca2+-binding synaptotagmins that includes SYT3, SYT5, and SYT6, and that differs from the group containing SYT1
  • INTERACTION
    DNA
    RNA
    small molecule metal binding,
    calcium Ca2+
    protein
  • vesicular Ca2+-sensor for IGF1 containing vesicles that mediates rapid activity-dependent secretion of IGF1
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS