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FLASH GENE
Symbol SYT6 contributors: mct/npt/pgu - updated : 19-05-2010
HGNC name synaptotagmin VI
HGNC id 18638
EXPRESSION
Type ubiquitous
   expressed in (based on citations)
organ(s)
cell lineage
cell lines
fluid/secretion in sperm cells
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • an intravesicular N terminal domain
  • a single transmembrane (TM) region
  • two protein kinase C-homologous repeats (Ca2+ binding domains C2)
  • a conserved WHXL motif in the C terminus
    • mono polymer homomer , heteromer , complex
    HOMOLOGY
    interspecies ortholog to rattus Syt6
    Homologene
    FAMILY
  • synaptotagmin family
    • CATEGORY structural protein
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytosolic,vesicle
    basic FUNCTION
  • involved in synaptic membrane fusion
  • calcium-binding proteinthat participate in the exocytosis of synaptic vesicles
  • SYT3, SYT5, SYT6, and SYT10 exhibit similar Ca2+-dependent phospholipid- and SNARE-binding properties as SYT1, although with a higher apparent Ca2+-affinity
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • key component of the secretory machinery involved in acrosomal exocytosis
  • SYT10 belongs to a group of Ca2+-binding synaptotagmins that includes SYT3, SYT5, and SYT6, and that differs from the group containing SYT1 )
    • INTERACTION
    DNA
    RNA
    small molecule metal binding,
  • Ca2+
    • protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --low  
    by promoter methylation in colorectal cancer patients
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS