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FLASH GENE

Symbol

SYT6

contributors: mct/npt/pgu - updated : 19-05-2010

HGNC name	synaptotagmin VI
HGNC id	18638

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

Location	1p13.2      Physical location : 114.631.914 - 114.696.472
Synonym symbol(s)	SytVI

DNA

TYPE	functioning gene
STRUCTURE	64.56 kb     8 Exon(s)

Genomic sequence alignment details
10 Kb 5' upstream gene genomic sequence study

MAPPING

cloned

Y

linked

N

status

provisional

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_205848 8 - 4370 NP_995320 - 425 - 2001 11543631

EXPRESSION

Type	ubiquitous

expressed in	(based on citations)
organ(s)

cell lineage
cell lines
fluid/secretion	in sperm cells

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains	an intravesicular N terminal domain
	a single transmembrane (TM) region
	two protein kinase C-homologous repeats (Ca2+ binding domains C2)
	a conserved WHXL motif in the C terminus

mono polymer

homomer , heteromer , complex

HOMOLOGY

interspecies

ortholog to rattus Syt6

Homologene

FAMILY

synaptotagmin family

CATEGORY

structural protein

SUBCELLULAR LOCALIZATION	intracellular
	intracellular,cytoplasm,cytosolic,vesicle

basic FUNCTION	involved in synaptic membrane fusion
	calcium-binding proteinthat participate in the exocytosis of synaptic vesicles
	SYT3, SYT5, SYT6, and SYT10 exhibit similar Ca2+-dependent phospholipid- and SNARE-binding properties as SYT1, although with a higher apparent Ca2+-affinity

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component	key component of the secretory machinery involved in acrosomal exocytosis
	SYT10 belongs to a group of Ca2+-binding synaptotagmins that includes SYT3, SYT5, and SYT6, and that differs from the group containing SYT1 )

INTERACTION

DNA

RNA

small molecule	metal binding,
	Ca2+

protein

cell & other

REGULATION

ASSOCIATED DISORDERS

corresponding disease(s)

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function tumoral     --low   by promoter methylation in colorectal cancer patients

Susceptibility

Variant & Polymorphism

Candidate gene

Marker

Therapy target

ANIMAL & CELL MODELS