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FLASH GENE
Symbol SCAF11 contributors: mct - updated : 03-07-2019
HGNC name SR-related CTD-associated factor 11
HGNC id 10784
EXPRESSION
Type ubiquitous
constitutive of
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Digestiveintestinesmall intestine  highly
Hearing/Equilibriumear   highly
Lymphoid/Immunelymph node   highly
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • an arginine/serine-rich (RS) domain but lacking any known RNA-binding motifs
  • caspase-recruitment domain (CARD) interacting with the C-terminal WD40 propeller domain of WDR1 to promote cofilin-mediated actin depolymerization
  • a CTD interaction domain at the C terminus
    • HOMOLOGY
    interspecies homolog to murine Sfrs2ip
    Homologene
    FAMILY
  • splicing factor SR family
    • CATEGORY regulatory , RNA associated
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus,nucleoplasm,nuclear bodies,nuclear speckles
    basic FUNCTION
  • playing an essential role in pre-mRNA splicing
  • central regulator of multiple events, including cell migration, cytokine maturation and apoptosis, during inflammatory responses
  • pro-inflammatory caspase, regulating cell migration during inflammation
    • CELLULAR PROCESS nucleotide, RNA splicing
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • spliceosome assembly involved in the formation of both A and B splicing complexes of the commitment complex E
    • INTERACTION
    DNA
    RNA binding
    small molecule
    protein
  • binding to SFRS2,U2AF65
  • binding to RNA polymerase II, C terminal domain (CTD)
  • interacts physically and functionally with actin interacting protein 1 (WDR1), an activator of cofilin-mediated actin depolymerization, and regulates cell migration by promoting WDR1/Cofilin-mediated actin depolymerization
  • CASP4, CASP5, and SCAF11 directly bind endotoxin (LOS/LPS) and can be activated in the absence of any co-factors
  • SCAF11 enhanced the activation of CASP8 and extrinsic cell death machinery within the lower small intestine
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS