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FLASH GENE

Symbol

SCAF11

contributors: mct - updated : 03-07-2019

HGNC name	SR-related CTD-associated factor 11
HGNC id	10784

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

DNA

TYPE	functioning gene
STRUCTURE	71.49 kb     15 Exon(s)

MAPPING

cloned

Y

linked

N

status

tentative : very preliminary evidence

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed SFRS2IP 15 - 7596 164.5 1463 - -

EXPRESSION

Type	ubiquitous

constitutive of

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Digestive intestine small intestine     highly Hearing/Equilibrium ear       highly Lymphoid/Immune lymph node       highly

cell lineage

cell lines

fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains	an arginine/serine-rich (RS) domain but lacking any known RNA-binding motifs
	caspase-recruitment domain (CARD) interacting with the C-terminal WD40 propeller domain of WDR1 to promote cofilin-mediated actin depolymerization
	a CTD interaction domain at the C terminus

HOMOLOGY

interspecies

homolog to murine Sfrs2ip

Homologene

FAMILY

splicing factor SR family

CATEGORY

regulatory , RNA associated

SUBCELLULAR LOCALIZATION	intracellular
	intracellular,nucleus,nucleoplasm,nuclear bodies,nuclear speckles

basic FUNCTION	playing an essential role in pre-mRNA splicing
	central regulator of multiple events, including cell migration, cytokine maturation and apoptosis, during inflammatory responses
	pro-inflammatory caspase, regulating cell migration during inflammation

CELLULAR PROCESS

nucleotide, RNA splicing

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component

spliceosome assembly involved in the formation of both A and B splicing complexes of the commitment complex E

INTERACTION

DNA

RNA

binding

small molecule

protein	binding to SFRS2,U2AF65
	binding to RNA polymerase II, C terminal domain (CTD)
	interacts physically and functionally with actin interacting protein 1 (WDR1), an activator of cofilin-mediated actin depolymerization, and regulates cell migration by promoting WDR1/Cofilin-mediated actin depolymerization
	CASP4, CASP5, and SCAF11 directly bind endotoxin (LOS/LPS) and can be activated in the absence of any co-factors
	SCAF11 enhanced the activation of CASP8 and extrinsic cell death machinery within the lower small intestine

cell & other

REGULATION

ASSOCIATED DISORDERS

ANIMAL & CELL MODELS