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FLASH GENE
Symbol SCAF11 contributors: mct - updated : 03-07-2019
HGNC name SR-related CTD-associated factor 11
HGNC id 10784
Location 12q13.11      Physical location : -
Synonym name
  • CTD-associated SR protein 11
  • SC35-interacting protein
  • SR-related protein 129 kDa
  • renal carcinoma antigen NY-REN-40
  • splicing regulatory protein 129
  • splicing factor, arginine/serine-rich 2, interacting protein
    • Synonym symbol(s) CASP11, SIP1, SRRP129, SFRS2IP
    DNA
    TYPE functioning gene
    STRUCTURE 71.49 kb     15 Exon(s)
    MAPPING cloned Y linked N status tentative : very preliminary evidence
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    15 - 7596 164.5 1463 - -
    EXPRESSION
    Type ubiquitous
    constitutive of
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestiveintestinesmall intestine  highly
    Hearing/Equilibriumear   highly
    Lymphoid/Immunelymph node   highly
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • an arginine/serine-rich (RS) domain but lacking any known RNA-binding motifs
  • caspase-recruitment domain (CARD) interacting with the C-terminal WD40 propeller domain of WDR1 to promote cofilin-mediated actin depolymerization
  • a CTD interaction domain at the C terminus
    • HOMOLOGY
    interspecies homolog to murine Sfrs2ip
    Homologene
    FAMILY
  • splicing factor SR family
    • CATEGORY regulatory , RNA associated
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus,nucleoplasm,nuclear bodies,nuclear speckles
    basic FUNCTION
  • playing an essential role in pre-mRNA splicing
  • central regulator of multiple events, including cell migration, cytokine maturation and apoptosis, during inflammatory responses
  • pro-inflammatory caspase, regulating cell migration during inflammation
    • CELLULAR PROCESS nucleotide, RNA splicing
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • spliceosome assembly involved in the formation of both A and B splicing complexes of the commitment complex E
    • INTERACTION
    DNA
    RNA binding
    small molecule
    protein
  • binding to SFRS2,U2AF65
  • binding to RNA polymerase II, C terminal domain (CTD)
  • interacts physically and functionally with actin interacting protein 1 (WDR1), an activator of cofilin-mediated actin depolymerization, and regulates cell migration by promoting WDR1/Cofilin-mediated actin depolymerization
  • CASP4, CASP5, and SCAF11 directly bind endotoxin (LOS/LPS) and can be activated in the absence of any co-factors
  • SCAF11 enhanced the activation of CASP8 and extrinsic cell death machinery within the lower small intestine
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS