basic FUNCTION
| involved in neural mechanisms mediating the development of speech and language |
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transcriptional repressor playing an important role in the specification and differentiation of lung epithelium |
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playing a role in the development of corticostriatal and olivocerebellar circuits involved in motor control |
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involved in acquiring human speech/language ability |
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involved in multiple functions not related to higher cognitive functions, including sensorimotor integration and vocal learning in birds and lung development outside the CNS |
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crucial regulator of lung and esophageal development, underscoring the necessity of this transcription factor in the development of anterior foregut-derived tissues |
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implicated in developmental verbal dyspraxia, a speech and language disorder |
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is important for modulating the plasticity of relevant neural circuits |
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FOXP1 and FOXP2 may be involved in the determination of the cell type identities during late embryogenesis |
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has an important role in speech and language in humans, and its targets may have a critical function in the development and evolution of language circuitry |
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in combination with PBX3 and MEIS2, may play a pivotal role in the development of striosomal neurons of the striatum and the islands of Calleja |
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down-regulates both the SRPX2 and the PLAUR genes and this transcriptional regulation is lost when FOXP2 bears a pathogenic p.R553H mutation that is known to cause DVD (developmental verbal dyspraxia) |
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modulates neuronal network formation, by directly and indirectly regulating mRNAs involved in the development and plasticity of neuronal connections |
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FOXP2 might functionally regulate DISC1 expression |
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FOXP2, DISC1 and the NRXN family in a molecular network that, when altered, confers risk for neurodevelopmental conditions in which various aspects of linguistic and cognitive function are disturbed, possibly via aberrant synaptic function |
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implicated in the development of cortico-striatal circuits, which are involved in sensorimotor integration required for vocal motor learning |
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implicated in pathways regulating neurite outgrowth, axon guidance and synaptic plasticity, which is in agreement with a role of FOXP2 in the development of neural circuits for language development |