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| demonstrate a critical role for SHANK3 in the normal development of neuronal connectivity and establish causality between a disruption in the Shank3 gene and the genesis of autistic-like behaviours in mice ( | |
a mouse genetic model that mimics a human mutation of Shank3 that deletes the Homer-binding domain at the C terminus (& |
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916;C) and is associated with autism |
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Shank3(+/& |
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916;C) mice exhibit behavioral phenotypes that parallel symptoms of ASD |
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Shank3 mutant mice exhibit autistic-like behaviors, including impaired social interaction and repetitive behaviors |