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FLASH GENE
Symbol EFNA4 contributors: - updated : 21-04-2006
HGNC name ephrin-A4
HGNC id 3224
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
HOMOLOGY
Homologene
FAMILY
CATEGORY signaling , receptor membrane ligand ion channel
SUBCELLULAR LOCALIZATION     plasma membrane
text GPI anchored, membrane protein
basic FUNCTION
  • membrane bound (glycosyl-phosphatidylinositol linkage) ligand for Eph-related kinase receptor tyrosine
  • involved in short-range contact-mediated axonal guidance
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • EPHA7
  • ligand of MXSX2 and TWIST1
    • cell & other
    REGULATION
    Other expression regulated by MSX2 and TWIST1
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional germinal mutation      
    in non-syndromic craniosynostosis
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS