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FLASH GENE

Symbol

EFNA4

contributors: - updated : 21-04-2006

HGNC name	ephrin-A4
HGNC id	3224

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

Location	1q21-q22      Physical location : 155.036.212 - 155.042.027
Synonym name	ligand of eph-related kinase 4
	eph-related receptor tyrosine kinase ligand 4
Synonym symbol(s)	EPLG4, LERK4 , EFL4,

DNA

TYPE	functioning gene
STRUCTURE	5.00 kb     4 Exon(s)

Genomic sequence alignment details
10 Kb 5' upstream gene genomic sequence study

regulatory sequence	Promoter (CAAT box)
	Binding site   HRE
text structure	promoter contains cis elements directing the cell-specific expression.
	CCAAT box binding the transcription activator nuclear factor-Y (NF-Y).
	cis regulatory elements contributing to the transcription activity of the ephrin-A4 promoter.

MAPPING

cloned

Y

linked

status

provisional

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed EFNA4 Ia - - 1276 - 201 - Munthe membrane-bound protein. EFNA4 Ib - splicing 1110 EFNA4 Ic - splicing 1131 - 214 - Munthe a secreted molecule

EXPRESSION

Type

widely

constitutive of

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Digestive intestine large intestine colon       liver         Lymphoid/Immune lymph node       highly Reproductive female system uterus cervix       male system prostate     highly Respiratory respiratory tract larynx     highly Visual eye

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Connective bone

cell lineage

cell lines

fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains

HOMOLOGY

Homologene

FAMILY

CATEGORY

signaling , receptor membrane ligand ion channel

SUBCELLULAR LOCALIZATION	plasma membrane
text	GPI anchored, membrane protein

basic FUNCTION	membrane bound (glycosyl-phosphatidylinositol linkage) ligand for Eph-related kinase receptor tyrosine
	involved in short-range contact-mediated axonal guidance

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component

INTERACTION

DNA

RNA

small molecule

protein	EPHA7
	ligand of MXSX2 and TWIST1

cell & other

REGULATION

Other

expression regulated by MSX2 and TWIST1

ASSOCIATED DISORDERS

corresponding disease(s)

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function constitutional germinal mutation       in non-syndromic craniosynostosis

Susceptibility

Variant & Polymorphism

Candidate gene

Marker

Therapy target

ANIMAL & CELL MODELS