| Other morbid association(s)
|
| Type | Gene Modification | Chromosome rearrangement | Protein expression | Protein Function
|
|---|
| tumoral
|
|
|
| loss of function
| |
in breast carcinoma and in preinvasive lesions (ductal and lobular carcinoma in situ) | | tumoral
|
|
|
| loss of function
| |
by hypermethylation in prostate and a significant fraction of lung and pancreatic carcinomas | | tumoral
|
|
| --low
|
|
silenced due to methylation in a substantial fraction of breast, prostate, lung, and pancreatic carcinomas  | | tumoral
|
|
| --low
|
| |
silencing is associated with dense promoter region hypermethylation in esophageal cancer (methylation is an early event in dysplastic transformation) | |
