Other morbid association(s)
|
Type | Gene Modification | Chromosome rearrangement | Protein expression | Protein Function
|
---|
tumoral
|  
|  
|  
| loss of function
|
in breast carcinoma and in preinvasive lesions (ductal and lobular carcinoma in situ) | tumoral
|  
|  
|  
| loss of function
|
by hypermethylation in prostate and a significant fraction of lung and pancreatic carcinomas | tumoral
|  
|  
| --low
|  
|
silenced due to methylation in a substantial fraction of breast, prostate, lung, and pancreatic carcinomas | tumoral
|  
|  
| --low
|  
|
silencing is associated with dense promoter region hypermethylation in esophageal cancer (methylation is an early event in dysplastic transformation) | |