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FLASH GENE
Symbol PPAP2A contributors: KTN - updated : 26/09/2008
HGNC name phosphatidic acid phosphatase type 2A
HGNC id 9228
Location 5q11      Physical location : 54.720.684 - 54.830.873
Synonym name phosphatidic acid phosphohydrolase type 2A
Synonym symbol(s) PAP2A, LPP1, PAP2, LLP1a, PAP-2a, PAP2a2, PAPalpha1, PAP2alpha2
EC.number 3.1.3.4
DNA
TYPE functioning gene
STRUCTURE 110.19 kb     7 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked N status confirmed
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
6 splicing 1638 32 284 predominant in kidney, lung, placenta and liver Leung (1998)
  • also named PAP2-a1
  • containing an in-frame alternate exon within the coding region when compared to variant 2
  • 6 splicing 1641 32 285 predominant in heart and pancreas Leung (1998)
  • also named PAP2-a2
  • EXPRESSION
    Type ubiquitous
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestivepancreas exocrine   highly
     pharynx   moderately
    Nervousnerve   highly
    Reproductivefemale systemuterus  highly
     female systemplacenta  moderately
     male systemprostate  predominantly
    Urinarybladder   moderately
     kidney   moderately
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Connectiveadipose  moderately
    Connectivebone  highly
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • six transmembrane regions
  • a single conserved N-glycosylation site
  • conjugated GlycoP
    mono polymer homomer , dimer
    HOMOLOGY
    interspecies homolog to dog PPAP2A (92.1 pc)
    homolog to chimpanzee PPAP2A (99.7 pc)
    homolog to rattus Ppap2a (74.5 pc)
    homolog to murine Ppap2a (75.1 pc)
    Homologene
    FAMILY
  • PAP2 superfamily
  • PA-phosphatase related phosphoesterase family
  • CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm,cytosolic
    text
  • multi-pass membrane protein
  • basic FUNCTION
  • dephosphorylating exogenous bioactive glycerolipids and sphingolipids
  • catalyzing the conversion of phosphatidic acid (PA) to diacylglycerol (DG)
  • acting as a pivotal regulator of lysophosphatidic acid (LPA) signaling in the cardiovascular system
  • being the major enzyme responsible of dephosphorylating LPA in platelets, which terminates signaling actions of LPA
  • may control circulating, and possibly also regulate localized, LPA levels resulting from platelet activation
  • having little activity towards ceramide-1-phosphate (C-1-P) and sphingosine-1-phosphate (S-1-P)
  • involved in the activation of protein kinase C
  • CELLULAR PROCESS cell life, proliferation/growth
    cell migration & motility
    PHYSIOLOGICAL PROCESS
    text
  • germ cell migration
  • negative regulation of cell proliferation
  • PATHWAY
    metabolism lipid/lipoprotein
    signaling hormonal
  • androgen receptor signaling pathway
  • regulation of lipid metabolic process
  • a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    induced by androgens
    inhibited by sphingosine, zinc ions and propanolol
    Other expression directly regulated by p73
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --low  
    down-regulated in colon adenocarcinomas
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS