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FLASH GENE
Symbol PPAP2C contributors: KTN/npt - updated : 13/10/2008
HGNC name phosphatidic acid phosphatase type 2C
HGNC id 9230
Location 19p13      Physical location : 281.045 - 291.435
Synonym name
  • lipid phosphate phosphohydrolase 2
  • type-2 phosphatidic acid phosphatase-gamma
  • Synonym symbol(s) PAP2C, LPP2, PAP-2c, PAP2-g
    EC.number 3.1.3.4
    DNA
    TYPE functioning gene
    STRUCTURE 10.39 kb     6 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status confirmed
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    6 splicing 1327 32.4 288 - -
  • differing in the 5' region, including the 5' UTR and a part of the coding region, compared to variant 3
  • 6 splicing 1286 26 232 - -
  • differing in the 5' region compared to variant 3
  • the translation begins at a downstream start codon
  • 6 splicing 1394 34.3 309 - -
    EXPRESSION
    Type
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestiveintestine   predominantly
     pancreas exocrine   moderately
    Endocrineneuroendocrinepituitary  highly
    Reproductivefemale systemovary  highly
     female systemuterus  highly
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
    conjugated GlycoP
    mono polymer homomer , dimer
    HOMOLOGY
    interspecies homolog to dog PPAP2C (92.7 pc)
    homolog to cow PPAP2C (90.6 pc)
    homolog to rattus Ppap2c (91.2 pc)
    homolog to murine Ppap2c (90.5 pc)
    Homologene
    FAMILY
  • PAP2 superfamily
  • PA-phosphatase related phosphoesterase family
  • CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm
    basic FUNCTION
  • catalyzing the conversion of phosphatidic acid (PA) to diacylglycerol (DG)
  • hydrolyzing lysophosphatidic acid (LPA), ceramide-1-phosphate (C-1-P) and sphingosine-1-phosphate (S-1-P)
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    inhibited by sphingosine, zinc ions and propanolol
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS