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FLASH GENE
Symbol CDC42EP4 contributors: npt/mct - updated : 287/08/200
HGNC name CDC42 effector protein (Rho GTPase binding) 4
HGNC id 17147
Location 17q24-q25      Physical location : 71.279.763 - 71.308.143
Synonym name
  • binder of RhoGPTases 4
  • Cdc42 effector protein 4
  • Synonym symbol(s) KIAA1777, CEP4, BORG4, MGC17125, MGC3740
    DNA
    TYPE functioning gene
    STRUCTURE 28.38 kb     2 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    2 - 3121 37 356 - Olsen (2006)
    EXPRESSION
    Type ubiquitous
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Cardiovascularheart    
    Digestivemouth   highly
    Endocrinepancreas   highly
    Lymphoid/Immunethymus   highly
    Nervousbrain   highly
    Respiratorylung   highly
    Urinarykidney    
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Epithelialsecretoryglandularendocrine 
    Epithelialsecretoryglandularexocrine 
    Muscularstriatumskeletal  
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • conserved CRIB, BH1 and three BH3 domain
  • BH2 domain
  • HOMOLOGY
    interspecies ortholog to murine Borg4-pending
    homolog to Drosophila CG.7526
    homolog to C.elegans Y64G10A7
    Homologene
    FAMILY
  • CDC42 binding protein family
  • BORG/CEP family
  • CATEGORY regulatory
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm,cytoskeleton
    text membrane-associated
    basic FUNCTION
  • regulating the organisation of the actin cytoskeleton
  • may be playing a role in inducing actin filament assembly and cell shape control
  • CELLULAR PROCESS cell organization/biogenesis
    PHYSIOLOGICAL PROCESS
    text cell shape control
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule nucleotide,
  • GTP
  • protein
  • binding to CDC42
  • binding to TC10
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS