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FLASH GENE
Symbol EFNA1 contributors: mct - updated : 01-02-2016
HGNC name ephrin-A1
HGNC id 3221
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
HOMOLOGY
Homologene
FAMILY LERK family
CATEGORY signaling , receptor membrane
SUBCELLULAR LOCALIZATION extracellular
    plasma membrane
text GPI anchored, membrane protein
basic FUNCTION
  • membrane bound (glycosyl-phosphatidylinositol linkage) ligand for Eph-related kinase receptor tyrosine
  • alone or in synergy with S1P, can participate in blood vessel destabilization, a prerequisite for angiogenesis
  • serves as a critical negative regulator in the tumorigenesis of gliomas by down-regulating EPHA2 and PTK2
  • involved in short-range contact-mediated axonal guidance
  • potentially regulating cardiac valve development
  • EFNA1 and EFNA2, but not the EFNA3, EFNA4, EFNA5 cluster, regulate the members of the ubiquitin-associated proteolysis genes
  • promotes the motility of EPHA2-positive cardiac stem cells, facilitates their migration to the area of damage, and enhances cardiac repair
  • SBDS and EFNA1 directly catalyze EIF6 removal in mammalian cells by a mechanism that requires GTP binding and hydrolysis by EFNA1 but not phosphorylation of EIF6 Ser 235
  • direct role for SBDS and EFNA1 in catalyzing the translational activation of ribosomes
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • EPHA7
  • ligand of EPHA2
  • SOCS2-interacting protein, and binding requires the SOCS2 SH2 domain and EPHA2 activation loop autophosphorylation, which is stimulated by EFNA1 or by phosphotyrosine phosphatase inhibition
    • cell & other
    REGULATION
    induced by TNF-alpha and interleukin-1 beta
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    significantly elevated in ostosarcoma
    tumoral     --over  
    of EPHA2 and EFNA1 plays an important role in the progression of gastric adenocarcinoma
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
  • EFNA1 and EPHA2 may be useful serum markers for the detection of hepatocellular carcinoma development and progression, respectively
    • Therapy target
    ANIMAL & CELL MODELS