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FLASH GENE

Symbol

EFNA1

contributors: mct - updated : 01-02-2016

HGNC name	ephrin-A1
HGNC id	3221

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

EXPRESSION

Type	ubiquitous

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Digestive salivary gland       highly Reproductive female system placenta     highly   female system uterus cervix   highly

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Connective bone       Homo sapiens

cell lineage

cell lines

fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains

HOMOLOGY

Homologene

FAMILY

LERK family

CATEGORY

signaling , receptor membrane

SUBCELLULAR LOCALIZATION	extracellular
	plasma membrane
text	GPI anchored, membrane protein

basic FUNCTION	membrane bound (glycosyl-phosphatidylinositol linkage) ligand for Eph-related kinase receptor tyrosine
	alone or in synergy with S1P, can participate in blood vessel destabilization, a prerequisite for angiogenesis
	serves as a critical negative regulator in the tumorigenesis of gliomas by down-regulating EPHA2 and PTK2
	involved in short-range contact-mediated axonal guidance
	potentially regulating cardiac valve development
	EFNA1 and EFNA2, but not the EFNA3, EFNA4, EFNA5 cluster, regulate the members of the ubiquitin-associated proteolysis genes
	promotes the motility of EPHA2-positive cardiac stem cells, facilitates their migration to the area of damage, and enhances cardiac repair
	SBDS and EFNA1 directly catalyze EIF6 removal in mammalian cells by a mechanism that requires GTP binding and hydrolysis by EFNA1 but not phosphorylation of EIF6 Ser 235
	direct role for SBDS and EFNA1 in catalyzing the translational activation of ribosomes

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component

INTERACTION

DNA

RNA

small molecule

protein	EPHA7
	ligand of EPHA2
	SOCS2-interacting protein, and binding requires the SOCS2 SH2 domain and EPHA2 activation loop autophosphorylation, which is stimulated by EFNA1 or by phosphotyrosine phosphatase inhibition

cell & other

REGULATION

induced by

TNF-alpha and interleukin-1 beta

ASSOCIATED DISORDERS

corresponding disease(s)

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function tumoral     --over   significantly elevated in ostosarcoma tumoral     --over   of EPHA2 and EFNA1 plays an important role in the progression of gastric adenocarcinoma

Susceptibility

Variant & Polymorphism

Candidate gene
Marker	EFNA1 and EPHA2 may be useful serum markers for the detection of hepatocellular carcinoma development and progression, respectively
Therapy target

ANIMAL & CELL MODELS