basic FUNCTION
| membrane bound (glycosyl-phosphatidylinositol linkage) ligand for Eph-related kinase receptor tyrosine |
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alone or in synergy with S1P, can participate in blood vessel destabilization, a prerequisite for angiogenesis |
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serves as a critical negative regulator in the tumorigenesis of gliomas by down-regulating EPHA2 and PTK2 |
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involved in short-range contact-mediated axonal guidance |
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potentially regulating cardiac valve development |
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EFNA1 and EFNA2, but not the EFNA3, EFNA4, EFNA5 cluster, regulate the members of the ubiquitin-associated proteolysis genes |
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promotes the motility of EPHA2-positive cardiac stem cells, facilitates their migration to the area of damage, and enhances cardiac repair |
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SBDS and EFNA1 directly catalyze EIF6 removal in mammalian cells by a mechanism that requires GTP binding and hydrolysis by EFNA1 but not phosphorylation of EIF6 Ser 235 |
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direct role for SBDS and EFNA1 in catalyzing the translational activation of ribosomes |