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FLASH GENE
Symbol EFNA1 contributors: mct - updated : 01-02-2016
HGNC name ephrin-A1
HGNC id 3221
Location 1q22      Physical location : 155.100.348 - 155.107.384
Synonym name
  • tumor necrosis factor, alpha-induced protein 4
  • eph-related receptor tyrosine kinase ligand 1
  • immediate early response protein B61
    • Synonym symbol(s) EPLG1, LERK1, TNFAIP4, B61, ECKLG, EFL1, LERK-1
    DNA
    TYPE functioning gene
    SPECIAL FEATURE overlapping
    text GMAN, long noncoding RNA (lncRNA) gene overlaps with the ephrin A1 gene (EFNA1)
    STRUCTURE 7.04 kb     5 Exon(s)
    Genomic sequence alignment details
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked   status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    5 - 1590 - 205 - 2001 11519828
    4 - 1524 - 183 - 2001 11519828
    EXPRESSION
    Type ubiquitous
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestivesalivary gland   highly
    Reproductivefemale systemplacenta  highly
     female systemuteruscervix highly
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Connectivebone    Homo sapiens
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
    HOMOLOGY
    Homologene
    FAMILY LERK family
    CATEGORY signaling , receptor membrane
    SUBCELLULAR LOCALIZATION extracellular
        plasma membrane
    text GPI anchored, membrane protein
    basic FUNCTION
  • membrane bound (glycosyl-phosphatidylinositol linkage) ligand for Eph-related kinase receptor tyrosine
  • alone or in synergy with S1P, can participate in blood vessel destabilization, a prerequisite for angiogenesis
  • serves as a critical negative regulator in the tumorigenesis of gliomas by down-regulating EPHA2 and PTK2
  • involved in short-range contact-mediated axonal guidance
  • potentially regulating cardiac valve development
  • EFNA1 and EFNA2, but not the EFNA3, EFNA4, EFNA5 cluster, regulate the members of the ubiquitin-associated proteolysis genes
  • promotes the motility of EPHA2-positive cardiac stem cells, facilitates their migration to the area of damage, and enhances cardiac repair
  • SBDS and EFNA1 directly catalyze EIF6 removal in mammalian cells by a mechanism that requires GTP binding and hydrolysis by EFNA1 but not phosphorylation of EIF6 Ser 235
  • direct role for SBDS and EFNA1 in catalyzing the translational activation of ribosomes
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • EPHA7
  • ligand of EPHA2
  • SOCS2-interacting protein, and binding requires the SOCS2 SH2 domain and EPHA2 activation loop autophosphorylation, which is stimulated by EFNA1 or by phosphotyrosine phosphatase inhibition
    • cell & other
    REGULATION
    induced by TNF-alpha and interleukin-1 beta
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    significantly elevated in ostosarcoma
    tumoral     --over  
    of EPHA2 and EFNA1 plays an important role in the progression of gastric adenocarcinoma
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
  • EFNA1 and EPHA2 may be useful serum markers for the detection of hepatocellular carcinoma development and progression, respectively
    • Therapy target
    ANIMAL & CELL MODELS