Selected-GenAtlas references SOURCE GeneCards NCBI Gene Swiss-Prot Ensembl
HGNC UniGene Nucleotide OMIM UCSC
Home Page
FLASH GENE
Symbol CDC42EP3 contributors: npt/mct - updated : 24/10/2008
HGNC name CDC42 effector protein (Rho GTPase binding) 3
HGNC id 16943
Location 2p21      Physical location : 37.870.742 - 37.899.326
Synonym name
  • binder of RhoGTPases 2
  • CDC42 effector protein 3
  • MSE55-related Cdc42-binding protein
  • Synonym symbol(s) CEP3, UB1, BORG2, FLJ46903
    DNA
    TYPE functioning gene
    STRUCTURE 28.58 kb     2 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    2 - 3981 27 254 - Olsen (2006)
    EXPRESSION
    Type ubiquitous
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Cardiovascularheart   highly
    Digestiveliver   lowly
    Endocrinepancreas    
    Lymphoid/Immunelymph node   highly
    Nervousbrain   lowly
    Reproductivemale systemprostate  highly
    Urinarykidney    
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Epithelialsecretoryglandularendocrine 
    Epithelialsecretoryglandularexocrine 
    Muscularstriatumskeletal  
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • a CRIB (Cdc42/Rac interactive-binding) domain
  • a conserved 12-residue BORG homology-1 (BH1) domain in its N terminus
  • an 11-amino acid BH2 domain in its central region
  • a 22-residue BH3 domain in its C terminus
  • HOMOLOGY
    interspecies homolog to Drosophila CG7526
    homolog to C.elegans Y64G10A7
    Homologene
    FAMILY
  • CDC42 binding protein family
  • BORG/CEP family
  • CATEGORY regulatory
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm,cytoskeleton
    basic FUNCTION regulator of mammalian septin organization
    CELLULAR PROCESS cell organization/biogenesis
    PHYSIOLOGICAL PROCESS
    text cell shape and cell size control
    PATHWAY
    metabolism
    signaling signal transduction
    a component
    INTERACTION
    DNA
    RNA
    small molecule nucleotide,
  • GTP
  • protein
  • binding to TC10 and CDC42 and cytoskeletal regulatory protein
  • bind to septin GTPases
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS