Selected-GenAtlas references SOURCE GeneCards NCBI Gene Swiss-Prot Ensembl
HGNC UniGene Nucleotide OMIM UCSC
Home Page
FLASH GENE
Symbol CDC42EP3 contributors: npt/mct - updated : 24/10/2008
HGNC name CDC42 effector protein (Rho GTPase binding) 3
HGNC id 16943
Location 2p21      Physical location : 37.870.742 - 37.899.326
Synonym name
  • binder of RhoGTPases 2
  • CDC42 effector protein 3
  • MSE55-related Cdc42-binding protein
  • Synonym symbol(s) CEP3, UB1, BORG2, FLJ46903
    DNA
    TYPE functioning gene
    STRUCTURE 28.58 kb     2 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    Physical map
    MRPL50P1 2p22.3 similar to Zinc finger protein 19 (Zinc finger protein KOX12) CRIM1 2p21 cysteine-rich motor neuron 1 FEZ2 2p21 fasciculation and elongation protein zeta 2 (zygin II) VIT 2p22-p21 vitrin STRN 2p22-p21 striatin, calmodulin binding protein KIAA1414 2p22.3 KIAA1414 protein FLJ38348 2p22.3 hypothetical protein FLJ38348 PRKR 2p22-p21 protein kinase, interferon-inducible double stranded RNA dependent LOC391365 2 similar to sulfotransferase CBF2 2p23.1 similar to sulfotransferase PRO1853 2p22.3 hypothetical protein PRO1853 PRKCN 2p21 protein kinase C, nu QPCT 2p22.3 glutaminyl-peptide cyclotransferase (glutaminyl cyclase) CDC42EP3 2p21 CDC42 effector protein (Rho GTPase binding) 3 LOC344382 2p22.3 similar to UNR-interacting protein (WD-40 repeat protein PT-WD) (MAP activator with WD repeats) FLJ32954 2p22.3 hypothetical protein FLJ32954 CYP1B1 2p21 cytochrome P450, family 1, subfamily B, polypeptide 1 MGC34824 2p22.3 hypothetical protein MGC34824 LOC391366 2 similar to ribosomal protein L7 LOC391367 2 similar to Glyceraldehyde 3-phosphate dehydrogenase, liver (GAPDH) ARL6IP2 2p22.3 similar to Glyceraldehyde 3-phosphate dehydrogenase, liver (GAPDH) LOC388940 2 LOC388940 LOC220717 2p22.3 similar to BLOCK 23 LOC92906 2p22.3 hypothetical protein BC008217 LOC130589 SFRS7 2p22-p21 splicing factor, arginine/serine-rich 7, 35kDa GEMIN6 2p22.3 gem (nuclear organelle) associated protein 6 DHX57 2p22.3 DEAH (Asp-Glu-Ala-Asp/His) box polypeptide 57 ASSP2 6q14.3-q15 argininosuccinate synthetase pseudogene 2 LOC387626 2 hypothetical gene supported by NM_144995 MOPT  protein containing single MORN motif in testis SOS1 2p22-p21 son of sevenless homolog 1 (Drosophila) LOC344387 2p22.3 similar to cyclin-dependent kinase-like 1 (CDC2-related kinase) MAP4K3 2p22.2 mitogen-activated protein kinase kinase kinase kinase 3 MGC33926 2p22.2 hypothetical protein MGC33926 C2orf8 2p22-p21 chromosome 2 open reading frame 8 LOC391368 2 similar to Zinc finger protein 19 (Zinc finger protein KOX12) SLC8A1 2p23-p22 solute carrier family 8 (sodium/calcium exchanger), member 1
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    2 - 3981 27 254 - Olsen (2006)
    EXPRESSION
    Type ubiquitous
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Cardiovascularheart   highly
    Digestiveliver   lowly
    Endocrinepancreas    
    Lymphoid/Immunelymph node   highly
    Nervousbrain   lowly
    Reproductivemale systemprostate  highly
    Urinarykidney    
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Epithelialsecretoryglandularendocrine 
    Epithelialsecretoryglandularexocrine 
    Muscularstriatumskeletal  
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • a CRIB (Cdc42/Rac interactive-binding) domain
  • a conserved 12-residue BORG homology-1 (BH1) domain in its N terminus
  • an 11-amino acid BH2 domain in its central region
  • a 22-residue BH3 domain in its C terminus
  • HOMOLOGY
    interspecies homolog to Drosophila CG7526
    homolog to C.elegans Y64G10A7
    Homologene
    FAMILY
  • CDC42 binding protein family
  • BORG/CEP family
  • CATEGORY regulatory
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm,cytoskeleton
    basic FUNCTION regulator of mammalian septin organization
    CELLULAR PROCESS cell organization/biogenesis
    PHYSIOLOGICAL PROCESS
    text cell shape and cell size control
    PATHWAY
    metabolism
    signaling signal transduction
    a component
    INTERACTION
    DNA
    RNA
    small molecule nucleotide,
  • GTP
  • protein
  • binding to TC10 and CDC42 and cytoskeletal regulatory protein
  • bind to septin GTPases
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS