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FLASH GENE

Symbol

VENTX

contributors: mct - updated : 14-08-2012

HGNC name	VENT homeobox homolog (Xenopus laevis)
HGNC id	13639

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

ASSOCIATED DISORDERS

corresponding disease(s)

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function constitutional     --other   aberrant expression of VENTX in normal CD34+ progenitor cells perturbs normal hematopoietic development, promoting generation of myeloid cells and impairing generation of lymphoid cells tumoral     --other   aberrantly expressed in malignant myeloid cells with particularly high expression in AML cases with t(8;21) or normal karyotype tumoral     --low   in chronic lymphocytic leukemia tumoral     --other   altered expression associated with corresponding changes of LEF1 target oncogenes such as CCND1, suggesting a potential role of VENTX in the clinical behavior of hematopoietic malignancies

Susceptibility

Variant & Polymorphism

Candidate gene

Marker

Therapy target

ANIMAL & CELL MODELS