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FLASH GENE

Symbol

VENTX

contributors: mct - updated : 14-08-2012

HGNC name	VENT homeobox homolog (Xenopus laevis)
HGNC id	13639

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_014468 3 - 2428 NP_055283 28 258 - 2010 20833819

EXPRESSION

Type

expressed in	(based on citations)
organ(s)

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Blood / hematopoietic plasma     predominantly Homo sapiens

cells

System Cell Pubmed Species Stage Rna symbol Blood/Hematopoietic mature hematopoietic Homo sapiens Blood/Hematopoietic myelocyte Homo sapiens

cell lineage
cell lines	erythroleukemic cell lines
fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains	N terminal proline-serine-threonine-rich domain
	homeobox domain
	C terminal proline-rich domain

HOMOLOGY

interspecies

homolog to xenopus xvent2b

Homologene

FAMILY

VENT homeoprotein family

CATEGORY

transcription factor

SUBCELLULAR LOCALIZATION

intracellular,nucleus

basic FUNCTION	might act as a potential tumor suppressor by controlling LEF1-mediated transcription
	LEF1-associated inhibitor of canonical Wnt/beta-catenin signaling and a negative regulator of cell proliferation
	role for VENTX in normal and malignant myelopoiesis
	unique regulatory factor of normal and leukemic postnatal hematopoietic cells
	having ability to promote a myeloid fate on early hematopoietic progenitor cells while suppressing erythroid differentiation
	more involved in myeloid differentiation pathways than in stem cell or lymphoid cell development
	is a novel regulator of human Hematopoietic Stem/Multipotent Progenitor Cells expansion
	anti-proliferation and pro-differentiation factor in human hematopoietic cells
	regulates the expression of several cell cycle regulators and Wnt downstream genes implicated in HSC/MPP proliferation and differentiation

CELLULAR PROCESS

nucleotide, transcription

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component

INTERACTION

DNA

RNA

small molecule

protein

inhibitor of the oncogenic Wnt and as an activator of the TP53/CDKN1A and CDKN2A/RB1 tumor suppressor pathways

cell & other

REGULATION

ASSOCIATED DISORDERS

corresponding disease(s)

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function constitutional     --other   aberrant expression of VENTX in normal CD34+ progenitor cells perturbs normal hematopoietic development, promoting generation of myeloid cells and impairing generation of lymphoid cells tumoral     --other   aberrantly expressed in malignant myeloid cells with particularly high expression in AML cases with t(8;21) or normal karyotype tumoral     --low   in chronic lymphocytic leukemia tumoral     --other   altered expression associated with corresponding changes of LEF1 target oncogenes such as CCND1, suggesting a potential role of VENTX in the clinical behavior of hematopoietic malignancies

Susceptibility

Variant & Polymorphism

Candidate gene

Marker

Therapy target

ANIMAL & CELL MODELS