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FLASH GENE
Symbol UBE2C contributors: mct/npt - updated : 14/10/2008
HGNC name ubiquitin-conjugating enzyme E2C
HGNC id 15937
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
HOMOLOGY
interspecies homolog to rattus Ube2c (96.1 pc)
homolog to murine Ube2c (95.5 pc)
Homologene
FAMILY
  • E2 ubiquitin-conjugating enzyme family
    • CATEGORY enzyme , regulatory
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytosolic
    intracellular,cytoplasm,cytoskeleton,microtubule,mitotic spindle
    intracellular,nucleus,nucleoplasm
    basic FUNCTION
  • catalyzing the covalent attachment of ubiquitin to other proteins
  • required for the destruction of mitotic cyclins
  • involved in negative regulation of ubiquitin-protein ligase activity during mitotic cell cycle
  • with UBE2S, likely constitute the physiological E2 module for the ANAPC during mitosis, in which UBE2C initiates and UBE2S elongates K11-linked ubiquitin chains (Williuamson 2009)
  • with UBE2C, constitute a physiological E2-module for ANAPC, the activity of which is required for spindle assembly and cell division (Williuamson 2009)
    • CELLULAR PROCESS cell cycle, division, mitosis
    protein, ubiquitin dependent proteolysis
    PHYSIOLOGICAL PROCESS
    text
  • positive regulation of exit from mitosis
  • spindle organization and biogenesis
    • PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • CDC20 transcriptionally up-regulates UBE2C expression through its WD40 domain
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    in malignant breast carcinomas (Berlingieri 2009)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target therapy of aggressive breast carcinomas based on the suppression of the UBE2C function (Berlingieri 2007)
    ANIMAL & CELL MODELS