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FLASH GENE

Symbol

UBE2C

contributors: mct/npt - updated : 14/10/2008

HGNC name	ubiquitin-conjugating enzyme E2C
HGNC id	15937

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

Location	20q13.12      Physical location : 44.441.254 - 44.445.594
Synonym name	cyclin-selective ubiquitin carrier protein
	mitotic-specific ubiquitin-conjugating enzyme
	ubiquitin carrier protein E2-C
Synonym symbol(s)	UBCH10, dJ447F3.2
EC.number	6.3.2.19

DNA

TYPE	functioning gene
STRUCTURE	4.34 kb     6 Exon(s)

10 Kb 5' upstream gene genomic sequence study

MAPPING

cloned

Y

linked

N

status

confirmed

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_007019 6 splicing 823 NP_008950 19.5 179 - - NM_181799 6 splicing 766 NP_861515 17.2 161 - - having an alternate internal exon compared to variant 1 NM_181800 5 splicing 744 NP_861516 16.5 150 - - lacking an internal exon compared to variant 1 NM_181801 6 splicing 918 NP_861517 15.6 140 - - having an alternate 5' exon compared to variant 1 using a downstream start codon encoding the same protein than variant 5 NM_181802 5 splicing 1490 NP_861518 15.6 140 - - having an additional segment in the 5' region compared to variant 1 using a downstream start codon encoding the same protein than variant 4 NM_181803 4 splicing 520 NP_861519 5 50 - - lacking two internal exons compared to variant 1

EXPRESSION

Type

expressed in

(based on citations)

organ(s)

System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Digestive intestine       highly   liver       moderately   pancreas exocrine       moderately   stomach       moderately Hearing/Equilibrium ear       highly Lymphoid/Immune tonsils       predominantly Nervous nerve       moderately Reproductive female system ovary     moderately   female system uterus     moderately   female system breast mammary gland   moderately

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Connective bone     highly

cell lineage
cell lines
fluid/secretion	highly in lymph

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains

HOMOLOGY

interspecies	homolog to rattus Ube2c (96.1 pc)
	homolog to murine Ube2c (95.5 pc)

Homologene

FAMILY

E2 ubiquitin-conjugating enzyme family

CATEGORY

enzyme , regulatory

SUBCELLULAR LOCALIZATION	intracellular
	intracellular,cytoplasm,cytosolic
	intracellular,cytoplasm,cytoskeleton,microtubule,mitotic spindle
	intracellular,nucleus,nucleoplasm

basic FUNCTION	catalyzing the covalent attachment of ubiquitin to other proteins
	required for the destruction of mitotic cyclins
	involved in negative regulation of ubiquitin-protein ligase activity during mitotic cell cycle
	with UBE2S, likely constitute the physiological E2 module for the ANAPC during mitosis, in which UBE2C initiates and UBE2S elongates K11-linked ubiquitin chains (Williuamson 2009)
	with UBE2C, constitute a physiological E2-module for ANAPC, the activity of which is required for spindle assembly and cell division (Williuamson 2009)

CELLULAR PROCESS	cell cycle, division, mitosis
	protein, ubiquitin dependent proteolysis

PHYSIOLOGICAL PROCESS

text	positive regulation of exit from mitosis
	spindle organization and biogenesis

PATHWAY

metabolism

signaling

a component

INTERACTION

DNA

RNA

small molecule

protein

CDC20 transcriptionally up-regulates UBE2C expression through its WD40 domain

cell & other

REGULATION

ASSOCIATED DISORDERS

corresponding disease(s)

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function tumoral     --over   in malignant breast carcinomas (Berlingieri 2009)

Susceptibility

Variant & Polymorphism

Candidate gene
Marker
Therapy target	therapy of aggressive breast carcinomas based on the suppression of the UBE2C function (Berlingieri 2007)

ANIMAL & CELL MODELS