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FLASH GENE
Symbol ELF4 contributors: mct - updated : 05-02-2008
HGNC name E74-like factor 4 (ets domain transcription factor)
HGNC id 3319
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a N terminal A transactivation domain
  • a central AT hook domain
  • a nuclear localization sequence
  • a C terminal ETS binding protein
    • HOMOLOGY
    interspecies ortholog to murine Elf4
    homolog to Drosophila Eip74EF
    homolog to C.elegans C24A1.2
    intraspecies homolog to ELF1 related
    Homologene
    FAMILY
  • elf-1/E74 family of ETS transcription factors
    • CATEGORY DNA associated , transcription factor
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus
    basic FUNCTION
  • ETS-related transcription factor with strong transcriptional activating activity that affects hematopoietic stem cell behavior and is required for normal NK cell and NK T-cell development
  • activating transcription from the promoters of GM-CSF and IL3
  • regulating the proliferation of primitive hematopoietic progenitor cells at steady state, controlling their quiescence
  • plays an important role in the decision of stem/primitive progenitor cells to divide or remain quiescent by regulating their entry to the cell cycle
  • is involved in PTH suppression of osteoblasts through activating the MAP2K4/MAPK8 pathway and subsequently up-regulating MAB21L1 expression
    • CELLULAR PROCESS nucleotide, transcription, regulation
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA binding
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    repressed by several leukemia-associated fusion transcription factor proteins (PML-retinoic acid receptor alpha and AML1-ETO)
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral   translocation    
    targeted by the t(X;21)(q26;q22) in acute myelogenous leukemia
    tumoral fusion      
    fused to ERG in a case of acute myeloid leukemia with a t(X;21)(q25-26;q22)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS