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FLASH GENE

Symbol

ELF4

contributors: mct - updated : 05-02-2008

HGNC name	E74-like factor 4 (ets domain transcription factor)
HGNC id	3319

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

EXPRESSION

Type

widely

constitutive of

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Cardiovascular heart         Digestive intestine       moderately   liver         Endocrine parathyroid       highly Lymphoid/Immune spleen       moderately Nervous brain         Reproductive female system ovary         male system prostate       Urinary bladder       highly

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Lymphoid

cells

System Cell Pubmed Species Stage Rna symbol Lymphoid/Immune lymphocyte

cell lineage

cell lines

fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains	a N terminal A transactivation domain
	a central AT hook domain
	a nuclear localization sequence
	a C terminal ETS binding protein

HOMOLOGY

interspecies	ortholog to murine Elf4
	homolog to Drosophila Eip74EF
	homolog to C.elegans C24A1.2

intraspecies

homolog to ELF1 related

Homologene

FAMILY

elf-1/E74 family of ETS transcription factors

CATEGORY

DNA associated , transcription factor

SUBCELLULAR LOCALIZATION	intracellular
	intracellular,nucleus

basic FUNCTION	ETS-related transcription factor with strong transcriptional activating activity that affects hematopoietic stem cell behavior and is required for normal NK cell and NK T-cell development
	activating transcription from the promoters of GM-CSF and IL3
	regulating the proliferation of primitive hematopoietic progenitor cells at steady state, controlling their quiescence
	plays an important role in the decision of stem/primitive progenitor cells to divide or remain quiescent by regulating their entry to the cell cycle
	is involved in PTH suppression of osteoblasts through activating the MAP2K4/MAPK8 pathway and subsequently up-regulating MAB21L1 expression

CELLULAR PROCESS

nucleotide, transcription, regulation

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component

INTERACTION

DNA

binding

RNA

small molecule

protein

cell & other

REGULATION

repressed by

several leukemia-associated fusion transcription factor proteins (PML-retinoic acid receptor alpha and AML1-ETO)

ASSOCIATED DISORDERS

corresponding disease(s)

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function tumoral   translocation     targeted by the t(X;21)(q26;q22) in acute myelogenous leukemia tumoral fusion       fused to ERG in a case of acute myeloid leukemia with a t(X;21)(q25-26;q22)

Susceptibility

Variant & Polymorphism

Candidate gene

Marker

Therapy target

ANIMAL & CELL MODELS