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FLASH GENE

Symbol

TRPV4

contributors: mct/ - updated : 09-10-2017

HGNC name	transient receptor potential cation channel, subfamily V, member 4
HGNC id	18083

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

ANIMAL & CELL MODELS

	TRPV4-deficient mice displayed impairment of the intercellular junction-dependent barrier function in the skin
	chondrocytes from Trpv4-null mice do not respond to hypo-osmotic stress suggesting that the mechanosensory role of TRPV4 is important in articular cartilage
	pharmacological inhibition of Trpv4 in mice modulate both thermogenic and proinflammatory pathways in fat, resulting in a robust resistance to obesity and insulin resistance