| basic FUNCTION
| Ca2+ permeable, non selective cation channel, be involved in the regulation of systemic osmotic pressure |
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may be playing a role in the regulation of body osmolarity, mechanosensation, temperature sensing, vascular regulation and, possibly, hearing |
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regulates the SOX9 pathway and contributes to the process of chondrogenesis |
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displays a widespread expression in various cells and tissues and has been implicated in diverse physiological processes, including osmotic homeostasis, thermo- and mechanosensation, vasorelaxation, tuning of neuronal excitability, and bladder voiding |
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has a functional role in keratinocyte cell volume regulation |
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plays a crucial role in regulating airway epithelial barrier function, epithelial and endothelial permeability, smooth muscle contraction and mucociliary transport  |
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mediate Ca2+ influx (assumed to act as a trigger of regulatory volume decrease) in response to osmotic stress |
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contains an additional voltage-dependent gating mechanism in series with the main intracellular gate |
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having a role in the development and maturation of cell-cell junctions in epithelia of the skin |
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involved in the actin remodeling, which is important for development and maturation of cell-cell contacts induced by the Ca2+ switch |
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plays an important role in the formation and/or maintenance of functional intercellular barriers |
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its activation leads to a retraction of the lamellipodia and to a decrease in migratory behaviour |
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TRPV4 and AQP4 combined possess the essential features expected of a regulatory volume decrease (RVD) activator |
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mediates neurotrophic factor-driven neuritogenesis in peripheral neurons |
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is essential for axonal growth of sensory/motor nerves in early development as well as for their maintenance in the adult |
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TRPV4 channel function may be modulated by TUBB and ANXA2 and their interactions may play a role in the mechanosensation in the pathogenesis of neuropathic pain |
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important role in epidermal barrier function in human skin keratinocytes |
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mediates Ca(2+) influx in the late stage of osteoclast differentiation and thereby regulates Ca(2+) signaling |
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role of TRPV4 as a cell-autonomous mediator for both the thermogenic and proinflammatory programs in adipocytes |
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is a regulator of adipose oxidative metabolism, inflammation, and energy homeostasis |
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functional status of TRPV4, which underlies mechanosensitive Ca(2+) signaling in collecting duct cells, inversely correlates with renal cystogenesis in ARPKD (autosomal recessive polycystic kidney disease) |
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endothelial TRPV4 channels mediate dilation of cerebral arteries |
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role for TRPV4 finger loop three in the physiological response |
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glial cell-expressed TRPV4 is a potential key factor responsible for infrasound-induced neuronal impairment |
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suggested to play a role in the regulation of ciliary beat frequency (CBF) |
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may participate in mucociliary clearance and airway protection |
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male-specific regulator of bone metabolism, a determinant of bone strength, and a potential risk predictor for fractures through regulation of bone matrix mineralization and intra-cortical porosity |
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likely AKAP5, PRKCA, and TRPV4 channels form dynamic subcellular signaling domains that control Ca(2+) influx into arterial myocytes |
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