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FLASH GENE
Symbol CDH22 contributors: mct - updated : 18-10-2007
HGNC name cadherin-like 22
HGNC id 13251
Location 20q13.1      Physical location : 44.802.375 - 44.880.334
Synonym name
  • PB-cadherin
  • Synonym symbol(s) C20orf25, MGC39564, dJ998H6.1
    DNA
    TYPE like-sequence
    STRUCTURE 78.00 kb     11 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status confirmed
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    - - - 3675 - 828 - -
  • a 794 aa mature peptide of 85.6 kda
  • a 34 aa signal peptide ok 3.6 kda
  • EXPRESSION
    Type
    constitutive of
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Cardiovascularheart   moderately
    Digestivepancreas exocrine   highly
    Nervousbrain   predominantly
     nerve   predominantly
    Respiratoryrespiratory tractlarynx  highly
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • a 34 aa signal peptide ok 3.6 kda
  • five cadherin domains
  • a cytoplasmic tail
  • conjugated GlycoP
    isoforms Precursor a 794 aa mature peptide of 85.6 kda
    HOMOLOGY
    interspecies homolog to dog CDH22 (97.1 pc)
    homolog to murine Cdh22 (94.8 pc)
    Homologene
    FAMILY
  • cadherin superfamily
  • CATEGORY adhesion
    SUBCELLULAR LOCALIZATION     plasma membrane
    text
  • single-pass type I membrane protein
  • basic FUNCTION
  • playing a role in homophilic cell adhesion
  • may play an important role in morphogenesis and tissue formation in neural and non-neural cells during development and maintenance of the brain and neuroendocrine organs
  • calcium-dependent cell adhesion protein that may play a role in morphogenesis and tissue development and could be involved in the development of diabetes-related tissues, e.g., pancreas and liver
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS development , nervous system
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule metal binding,
  • Ca2+
  • protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility to type 2 diabetes mellitus
    Variant & Polymorphism SNP associated with the risk of type 2 diabetes mellitus
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS