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FLASH GENE
Symbol SLC13A3 contributors: mct - updated : 28-02-2014
HGNC name solute carrier family 13 (sodium-dependent dicarboxylate transporter), member 3
HGNC id 14430
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • di-hydrophobic amino acid motif VW as basolateral localization signal in the N-terminal cytoplasmic domain
  • three putative N linked glycosylation sites
  • twelve transmembrane domains
  • eight potential protein kinase C dependent phosphorylation sites
    • HOMOLOGY
    Homologene
    FAMILY
    CATEGORY transport carrier
    SUBCELLULAR LOCALIZATION     plasma membrane
    text synaptosomes
    basic FUNCTION
  • high-affinity sodium-dicarboxylate cotransporter that accepts a range of substrates with 4-5 carbon atoms
  • SLC13A2 , SLC13A5 and SLC13A3, transport di- and tri-carboxylate Krebs cycle intermediates such as succinate, citrate and alpha-ketoglutarate
  • participates in drug and xenobiotic excretion through interactions with organic anion transporters
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    text sodium sulfate symporter
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS