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FLASH GENE

Symbol

SLC13A3

contributors: mct - updated : 28-02-2014

HGNC name	solute carrier family 13 (sodium-dependent dicarboxylate transporter), member 3
HGNC id	14430

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

Location	20q12-q13.1      Physical location : 45.186.461 - 45.313.124
Synonym name	Na(+)/dicarboxylate cotransporter 3
	sodium-dependent high affinity dicarboxylate transporter 3
Synonym symbol(s)	NADC3, SDCT2

DNA

TYPE	functioning gene
STRUCTURE	126.00 kb     14 Exon(s)

10 Kb 5' upstream gene genomic sequence study

MAPPING

cloned

Y

linked

N

status

provisional

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed variant 1 14 - 4045 - 602 - Bai (2006) variant 2 - - 4066 - 655 - Bai (2006)

EXPRESSION

Type

widely

constitutive of

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Endocrine pancreas       moderately Hearing/Equilibrium ear       highly Reproductive female system placenta     highly Urinary kidney tubule convoluted tubule proximal tubule highly   kidney nephron

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Epithelial secretory glandular endocrine   Nervous central

cell lineage

cell lines

fluid/secretion

at STAGE

physiological period

pregnancy

Text

placenta

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains	di-hydrophobic amino acid motif VW as basolateral localization signal in the N-terminal cytoplasmic domain
	three putative N linked glycosylation sites
	twelve transmembrane domains
	eight potential protein kinase C dependent phosphorylation sites

HOMOLOGY

Homologene

FAMILY

CATEGORY

transport carrier

SUBCELLULAR LOCALIZATION	plasma membrane
text	synaptosomes

basic FUNCTION	high-affinity sodium-dicarboxylate cotransporter that accepts a range of substrates with 4-5 carbon atoms
	SLC13A2 , SLC13A5 and SLC13A3, transport di- and tri-carboxylate Krebs cycle intermediates such as succinate, citrate and alpha-ketoglutarate
	participates in drug and xenobiotic excretion through interactions with organic anion transporters

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

text	sodium sulfate symporter

PATHWAY

metabolism

signaling

a component

INTERACTION

DNA

RNA

small molecule

protein

cell & other

REGULATION

ASSOCIATED DISORDERS

ANIMAL & CELL MODELS