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FLASH GENE
Symbol SLC30A1 contributors: mct - updated : 22-10-2017
HGNC name solute carrier family 30 (zinc transporter), member 1
HGNC id 11012
EXPRESSION
Type widely
   expressed in (based on citations)
organ(s)
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • six membrane-spanning domains
  • a large intracellular loop
  • a C terminal tail (mouse)
    • HOMOLOGY
    interspecies ortholog to murine Znt1
    Homologene
    FAMILY
  • zinc transporter family
  • cation diffusion facilitator (CDF) transporter family
  • SLC30A subfamily
    • CATEGORY transport carrier
    SUBCELLULAR LOCALIZATION     plasma membrane
    basic FUNCTION
  • zinc transport out of the cell
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS exocytosis transport
    PATHWAY
    metabolism
    signaling
    a component TMEM163 dimerizes with itself but it also heterodimerizes with SLC30A1, SLC30A2, SLC30A3, and SLC30A4 proteins
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • cooperative zinc handling of SLC30A4, metallothionein and SLC30A1 in the cytoplasm is required for full activation of ALPL in the early secretory pathway (ESP), and present clear evidence that the activation process of zinc enzymes is elaborately controlled
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional     --low  
    in in the hippocampus/parahippocampal gyrus of preclinical stage of AD subjects
    constitutional     --low  
    significant decreases in placental MT1A and SLC30A1 mRNA expressions to the levels below the threshold values may be a crucial factor to determine the presence of fetal heart malformations, by zinc deficiency
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS