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FLASH GENE

Symbol

TOP1MT

contributors: mct - updated : 30-11-2015

HGNC name	topoisomerase (DNA) I, mitochondrial
HGNC id	29787

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

ANIMAL & CELL MODELS

Top1mt -/- murine embryonic fibroblasts (MEF) exhibit dysfunctional mitochondrial respiration, which leads decreased ATP production and compensation by increased glycolysis and fatty acid oxidation