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FLASH GENE

Symbol

TOP1MT

contributors: mct - updated : 30-11-2015

HGNC name	topoisomerase (DNA) I, mitochondrial
HGNC id	29787

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

EXPRESSION

Type	ubiquitous

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Digestive intestine small intestine     highly Nervous brain       highly Reproductive female system uterus cervix   highly

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Blood / hematopoietic bone marrow

cell lineage

cell lines

fluid/secretion

at STAGE

physiological period

fetal

Text	liver highly

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains

HOMOLOGY

interspecies	homolog to Drosophila top1
	ortholog to murine Top1mt
	ortholog to rattus top1mt

Homologene

FAMILY

eucaryotic type I topoisomerase family

CATEGORY

enzyme , DNA associated

SUBCELLULAR LOCALIZATION	intracellular
	intracellular,cytoplasm,organelle,mitochondria,matrix
	intracellular,nucleus
text	three different topoisomerases have been identified in mitochondria: TOP1MT, TOP3A and a truncated form of TOP2B

basic FUNCTION	DNA topoisomerase, type IB, DNA single strand break, binding covalently to the 3' end of the break
	controling and altering the topologic states of DNA during transcription
	implicated for mitochondrial integrity and energy metabolism
	relaxes mitochondrial DNA (mtDNA) supercoiling by introducing transient cleavage complexes wherein the broken DNA strand swivels around the intact strand
	is required for normal mtDNA homeostasis and for linking mtDNA expansion with hepatocyte proliferation

CELLULAR PROCESS	nucleotide, chromatin organization, remodeling
	nucleotide, replication
	nucleotide, recombination
	nucleotide, transcription, regulation

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component

INTERACTION

DNA	binding to single strand

RNA

small molecule	metal binding,
	calcium Ca2+
	magnesium Mg2+

protein

cell & other

REGULATION

ASSOCIATED DISORDERS

corresponding disease(s)

Susceptibility

Variant & Polymorphism

Candidate gene

Marker

Therapy target

ANIMAL & CELL MODELS

Top1mt -/- murine embryonic fibroblasts (MEF) exhibit dysfunctional mitochondrial respiration, which leads decreased ATP production and compensation by increased glycolysis and fatty acid oxidation