SUBCELLULAR LOCALIZATION
| plasma membrane
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| intracellular
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| intracellular,cytoplasm,organelle,membrane
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| intracellular,cytoplasm,organelle,endoplasmic reticulum
|
| intracellular,cytoplasm,organelle,Golgi
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| intracellular,nucleus,nucleoplasm
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basic FUNCTION
| Ca2+-activated and voltage-dependent Ca2+-impermeable cation channel |
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implicated in physiological processes including T-cell activation, myogenic vasoconstriction, and cardiac function |
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playing a pivotal role in modulation of store-operated Ca2+ via interaction with TRPC3 |
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exceptional in that it is one of only two ion channels known in the mammalian genome that conduct monovalent cations exclusively and nonselectively |
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controls insulin secretion in pancreatic beta-cells, and may regulate calcium influx by causing the depolarization that drives the activation of voltage-dependent calcium channels |
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is a critical mediator of pressure-induced membrane depolarization and arterial constriction |
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TRPM4 is an important regulator of smooth muscle cell membrane depolarization and arterial constriction in response to intraluminal pressure |
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TRPM2, TRPM4 and TRPM5 control insulin secretion levels by sensing intracellular Ca2+ increase, NAD metabolites, or hormone receptor activation |
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ABCC8 and TRPM4 have an intrinsic capacity for stable co-association |
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TRPM4 and TRPM5 are both N-linked glycosylated at a unique site and also suggest that TRPM4/5 glycosylation seems not to be involved in channel trafficking, but mainly in their functional regulation |
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is potentially an important regulator of Ca2+ signals generated by histamine in adipose-derived stem cells (hASCs) and is required for adipogenesis |
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cell surface expression of TRPM4 channels is mediated by YWHAG binding, and the specific inhibition of this trafficking process can be a potential therapeutic target for glutamate-induced neuronal cell death |
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functions as a Ca(2+)-activated non-selective cation channel and constitutes a novel regulator of ventricular contractility |
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contributes to the regulation of driving force for store-operated calcium entry and thereby the activation of the calcineurin-NFAT pathway and the development of pathological cardiac hypertrophy |
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PLCB3, INPP5J interact with N-terminus region of TRPM4 channel |
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is a Ca2+-activated non-selective cationic channel (Ca2+-NSCC) that conducts monovalent but not divalent cations |