| basic FUNCTION
| membrane-bound sodium-borate cotransporter, playing an essential role in cell growth and proliferation in cells |
|
essential for borate homeostasis (Park et al, 2004) |
|
having a key role in the growth and terminal differentiation of neural crest cells during the formation of the endothelium |
|
essential for the generation of the endocochlear potential but not for regulation of potassium concentrations in the endolymph (Groger 2010) |
|
major role of SLC4A11 in ion homeostasis and fluid transport across various epithelial barriers (Groger 2010) |
|
role for mediating a sodium flux into the thin descending limb of Henle loop to allow countercurrent multiplication by osmotic equilibration (Groger 2010) |
|
necessary for cell survival which may explain the pathologic corneal endothelial cell loss in endotheliopathies due to SLC4A11 mutations  |
|
in corneal endothelium, SLC4A11 displays robust Na& |
|
8314;-coupled OH& |
|
8315; transport |
|
cooperative role of AQP1 and SLC4A11 in mediating trans-endothelial water reabsorption |
