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FLASH GENE
Symbol KCNIP2 contributors: npt/mct - updated : 18-12-2010
HGNC name Kv channel interacting protein 2
HGNC id 15522
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • four EF-Hands, calcium binding motif
  • two types of Ca2+-binding sites, and only one type of Mg2+-binding site
    • HOMOLOGY
    interspecies homolog to Kcnip2
    intraspecies homolog to KCHIP1,KCHIP3
    Homologene
    FAMILY
  • recoverin family
    • CATEGORY signaling , transport channel
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm
    basic FUNCTION
  • may be regulating A-type currents, and hence neuronal excitability, in response to changes in intracellular calcium
  • involved in gene regulation
  • direct regulator of the cardiac L-type Ca2+ current, multimodal regulator of cardiac ionic currents
  • can attenuate cardiac hypertrophy possibly through modulation of intracellular calcium concentration and calcineurin/NFAT pathway
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling signal transduction
    a component
  • complexing with KCND3
  • integral subunit component of native Kv4 chain complex
    • INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS