Selected-GenAtlas references SOURCE GeneCards NCBI Gene Swiss-Prot Orphanet Ensembl
HGNC UniGene Nucleotide OMIM UCSC
Home Page
FLASH GENE
Symbol DPM1 contributors: npt - updated : 09-05-2007
HGNC name dolichyl-phosphate mannosyltransferase polypeptide 1, catalytic subunit
HGNC id 3005
DNA
TYPE functioning gene
STRUCTURE 23.66 kb     9 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked N status provisional
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
9 - 1047 - 260 - Olsen (2006)
EXPRESSION
Type widely
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Digestivesalivary gland   highly
Urinarybladder   highly
cell lineage
cell lines
fluid/secretion
at STAGE
physiological period pregnancy
Text placenta
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • glycosyltransferase domain
  • lacking the C-terminal transmembrane domain present in the yeast homolog
  • a cAMP-dependent phosphorylation motif (Baksi 2008)
    • HOMOLOGY
    interspecies homolog to murine Dpm1
    homolog to S .cerevisiae dpm1
    Homologene
    FAMILY
  • glycosyltransferase 2 family
    • CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,lumen
    intracellular,cytoplasm,organelle,membrane
    intracellular,cytoplasm,organelle,endoplasmic reticulum
    basic FUNCTION
  • dolichol-P-mannose synthesis from GDP-mannose and dolichol-phosphate
  • transferring mannose from GDP-mannose to dolichol monophosphate to form dolichol phosphate mannose (dol-p-man) which is the mannosyl donor in pathways leading to N-glycosylation
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism carbohydrate
    signaling
    N-glycosylation
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    activated by DPM2
    Other increased activity through protein phosphorylation is a driving force for angiogeneis (Baksi 2008)
    ASSOCIATED DISORDERS
    corresponding disease(s) CDG1E
    related resource Congenital Disorder of Glycosylation pages
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS