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FLASH GENE
Symbol DPM1 contributors: npt - updated : 09-05-2007
HGNC name dolichyl-phosphate mannosyltransferase polypeptide 1, catalytic subunit
HGNC id 3005
Corresponding disease
CDG1E congenital disorder of glycosylation, type 1E
Location 20q13.13      Physical location : 49.551.404 - 49.575.060
Synonym name
  • dolichyl monophosphate mannose synthase
  • MPD synthase
  • dolichyl-phosphate beta-D- mannosyltransferase
  • Synonym symbol(s) MPDS
    EC.number 2.4.1.83
    DNA
    TYPE functioning gene
    STRUCTURE 23.66 kb     9 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    Physical map
    B4GALT5 20q13.1-q13.2 UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 5 SNRPFP1 20 small nuclear ribonucleoprotein polypeptide F pseudogene 1 SLC9A8 20q13.13 solute carrier family 9 (sodium/hydrogen exchanger), isoform 8 SPATA2 20q13.1-q13.2 spermatogenesis associated 2 ZNF313 20q13.13 zinc finger protein 313 LOC391256 20 similar to Keratin, type I cytoskeletal 18 (Cytokeratin 18) (K18) (CK 18) SNAI1 20q13.2 snail homolog 1 (Drosophila) LOC149738 20q13.13 hypothetical LOC149738 UBE2V1 20q13.2 ubiquitin-conjugating enzyme E2 variant 1 CEBPB 20q13.1 CCAAT/enhancer binding protein (C/EBP), beta COX6CP2 20 cytochrome c oxidase subunit VIc pseudogene 2 PTPN1 20q13.1-q13.2 protein tyrosine phosphatase, non-receptor type 1 LOC200230 20q13.13 similar to KIAA0386 C20orf175 20 chromosome 20 open reading frame 175 RPL36P2 20q13.1 ribosomal protein L36 pseudogene 2 PARD6B 20q13.13 par-6 partitioning defective 6 homolog beta (C. elegans) BCAS4 20q13.13-q13.2 breast carcinoma amplified sequence 4 TMSL6 20 thymosin-like 6 ADNP 20q13.3-q13.2 activity-dependent neuroprotector PSMD10P 20q13.13 proteasome (prosome, macropain) 26S subunit, non-ATPase, 10 pseudogene DPM1 20q13.13 dolichyl-phosphate mannosyltransferase polypeptide 1, catalytic subunit MOCS3 20 molybdenum cofactor synthesis 3 KCNG1 20q13 potassium voltage-gated channel, subfamily G, member 1 LAMR1P1 20q13.3 laminin receptor 1 pseudogene 1 NFATC2 20q13.2-q13.31 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 2 ATP9A 20q13.1-q13.2 ATPase, class II, type 9A SALL4 20q13.13-q13.2 sal-like 4 (Drosophila) ERP28P 20q13.13 endoplasmic reticulum lumenal protein 28 pseudogene ZFP64 20q13.13 zinc finger protein 64 homolog (mouse)
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    9 - 1047 - 260 - Olsen (2006)
    EXPRESSION
    Type widely
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestivesalivary gland   highly
    Urinarybladder   highly
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    physiological period pregnancy
    Text placenta
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • glycosyltransferase domain
  • lacking the C-terminal transmembrane domain present in the yeast homolog
  • a cAMP-dependent phosphorylation motif (Baksi 2008)
  • HOMOLOGY
    interspecies homolog to murine Dpm1
    homolog to S .cerevisiae dpm1
    Homologene
    FAMILY
  • glycosyltransferase 2 family
  • CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,lumen
    intracellular,cytoplasm,organelle,membrane
    intracellular,cytoplasm,organelle,endoplasmic reticulum
    basic FUNCTION
  • dolichol-P-mannose synthesis from GDP-mannose and dolichol-phosphate
  • transferring mannose from GDP-mannose to dolichol monophosphate to form dolichol phosphate mannose (dol-p-man) which is the mannosyl donor in pathways leading to N-glycosylation
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism carbohydrate
    signaling
    N-glycosylation
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    activated by DPM2
    Other increased activity through protein phosphorylation is a driving force for angiogeneis (Baksi 2008)
    ASSOCIATED DISORDERS
    corresponding disease(s) CDG1E
    related resource Congenital Disorder of Glycosylation pages
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS