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FLASH GENE
Symbol DPM1 contributors: npt - updated : 09-05-2007
HGNC name dolichyl-phosphate mannosyltransferase polypeptide 1, catalytic subunit
HGNC id 3005
Corresponding disease
CDG1E congenital disorder of glycosylation, type 1E
Location 20q13.13      Physical location : 49.551.404 - 49.575.060
Synonym name
  • dolichyl monophosphate mannose synthase
  • MPD synthase
  • dolichyl-phosphate beta-D- mannosyltransferase
    • Synonym symbol(s) MPDS
    EC.number 2.4.1.83
    DNA
    TYPE functioning gene
    STRUCTURE 23.66 kb     9 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    9 - 1047 - 260 - Olsen (2006)
    EXPRESSION
    Type widely
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestivesalivary gland   highly
    Urinarybladder   highly
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    physiological period pregnancy
    Text placenta
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • glycosyltransferase domain
  • lacking the C-terminal transmembrane domain present in the yeast homolog
  • a cAMP-dependent phosphorylation motif (Baksi 2008)
    • HOMOLOGY
    interspecies homolog to murine Dpm1
    homolog to S .cerevisiae dpm1
    Homologene
    FAMILY
  • glycosyltransferase 2 family
    • CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,lumen
    intracellular,cytoplasm,organelle,membrane
    intracellular,cytoplasm,organelle,endoplasmic reticulum
    basic FUNCTION
  • dolichol-P-mannose synthesis from GDP-mannose and dolichol-phosphate
  • transferring mannose from GDP-mannose to dolichol monophosphate to form dolichol phosphate mannose (dol-p-man) which is the mannosyl donor in pathways leading to N-glycosylation
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism carbohydrate
    signaling
    N-glycosylation
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    activated by DPM2
    Other increased activity through protein phosphorylation is a driving force for angiogeneis (Baksi 2008)
    ASSOCIATED DISORDERS
    corresponding disease(s) CDG1E
    related resource Congenital Disorder of Glycosylation pages
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS