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FLASH GENE

Symbol

KCNIP3

contributors: npt/mct - updated : 13-06-2017

HGNC name	Kv channel interacting protein 3, calsenilin
HGNC id	15523

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

ANIMAL & CELL MODELS

	Kcnip3 -/- mice displayed markedly reduced responses in models of acute thermal, mechanical, and visceral pain
	mice lacking Kcnip3 had elevated levels of prodynorphin mRNA and dynorphin A peptides in the spinal cord, and the reduction of pain behaviors in Dream -/- mice was mediated through dynorphin-selective kappa-opiate receptors
	Dream-deficient mice displayed persistent and unchecked A20 expression in response to endotoxin