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FLASH GENE

Symbol

KCNIP3

contributors: npt/mct - updated : 13-06-2017

HGNC name	Kv channel interacting protein 3, calsenilin
HGNC id	15523

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

ASSOCIATED DISORDERS

corresponding disease(s)

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function constitutional     --over   in the brains of Alzheimer disease and epilepsy patients, and may be due in part to decreased degradation of calsenilin, and that the dysfunction of proteasomal activity but not lysosomal activity contributes to accumulation of calsenilin in the ER constitutional     --low   promotes the degeneration of retinal ganglion cells (RGCs), amacrine cells, and bipolar cells

Susceptibility

Variant & Polymorphism

Candidate gene	may represent feasible target for therapeutic intervention in Alzheimer disease
Marker
Therapy target

ANIMAL & CELL MODELS

	Kcnip3 -/- mice displayed markedly reduced responses in models of acute thermal, mechanical, and visceral pain
	mice lacking Kcnip3 had elevated levels of prodynorphin mRNA and dynorphin A peptides in the spinal cord, and the reduction of pain behaviors in Dream -/- mice was mediated through dynorphin-selective kappa-opiate receptors
	Dream-deficient mice displayed persistent and unchecked A20 expression in response to endotoxin