Selected-GenAtlas references | SOURCE | GeneCards | NCBI Gene | Swiss-Prot | Ensembl |
HGNC | UniGene | Nucleotide | OMIM | UCSC |
Home Page |
FLASH GENE |
Symbol | ABCC11 | contributors: mct - updated : 08-12-2021 |
HGNC name | ATP-binding cassette, sub-family C (CFTR/MRP), member 11 |
HGNC id | 14639 |
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Location | 16q12.1 Physical location : 48.200.821 - 48.269.088 |
Synonym name | multi-resistance protein 8 |
Synonym symbol(s) | MRP8, EWWD, WW |
EC.number | 7.6.2.3/ 7.6.2.2 |
DNA |
TYPE | functioning gene |
SPECIAL FEATURE | arranged in tandem, opposite orientation |
text | tandemly located in a tail-to-head orientation with ABCC12 |
STRUCTURE | 85.13 kb 30 Exon(s) |
10 Kb 5' upstream gene genomic sequence study |
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MAPPING | cloned | Y | linked | N | status | provisional |
RNA |
TRANSCRIPTS | type | messenger |
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EXPRESSION |
Type | restricted |
expressed in | (based on citations) | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
organ(s) |
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tissue |
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cells |
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cell lineage
cell lines
| fluid/secretion
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at STAGE |
physiological period | fetal, pregnancy |
Text | lowly in placenta and fetal brain |
PROTEIN |
PHYSICAL PROPERTIES
STRUCTURE
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motifs/domains
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HOMOLOGY |
intraspecies | homolog to MRP5 |
Homologene |
FAMILY | ATP binding cassette transporter subfamily C (CFTR/MRP) |
CATEGORY | transport carrier |
SUBCELLULAR LOCALIZATION | plasma membrane |
intracellular | |
intracellular,cytoplasm,cytosolic,vesicle | |
intracellular,cytoplasm,cytoskeleton,microfilament | |
text | co-localized with neurofilaments indicating that it is an axonal protein |
basic FUNCTION | |
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CELLULAR PROCESS |
PHYSIOLOGICAL PROCESS |
PATHWAY |
metabolism |
signaling |
a component |
INTERACTION |
DNA |
RNA |
small molecule | nucleotide, |
ATP-binding |
protein |
cell & other |
REGULATION |
Other | N-linked glycosylation is likely important for the protein stability of ABCC11 |
ASSOCIATED DISORDERS |
corresponding disease(s) |
Other morbid association(s) |
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Susceptibility |
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Variant & Polymorphism SNP | |
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Candidate gene
Marker
| Therapy target
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ANIMAL & CELL MODELS |