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FLASH GENE
Symbol ANAPC5 contributors: mct - updated : 03-09-2010
HGNC name anaphase promoting complex subunit 5
HGNC id 15713
Location 12q24.31      Physical location : 121.746.049 - 121.792.012
Synonym name
  • periodontal ligament fibroblast protein
  • cyclosome subunit 5
  • Synonym symbol(s) APC5, PDL-108, PDL108
    DNA
    TYPE functioning gene
    STRUCTURE 44.22 kb     17 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    17 - 2625 85 755 - Yu (1998)
    17 - 2364 - 643 - Yu (1998)
    EXPRESSION
    Type ubiquitous
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Endocrinepancreas    
    Nervousbrain    
    Respiratorylung    
    Urinarykidney    
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Epithelialsecretoryglandularendocrine 
    Epithelialsecretoryglandularexocrine 
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • four tetratricopeptide (TPR) repeats
  • HOMOLOGY
    interspecies ortholog to murine Anapc5
    Homologene
    FAMILY
  • APC5 (anaphase-promoting complex) family
  • CATEGORY regulatory
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytosolic
    intracellular,nucleus,nucleoplasm
    basic FUNCTION
  • controlling progresion through anaphase by triggering the degradation of cell cycle regulators such securin and B-type cyclin
  • suppressing E1A-mediated transformation in a CBP/p300-dependent manner
  • involved in the regulation of IRES-mediated translation
  • orchestrates progression through mitosis by decorating cell-cycle regulators with ubiquitin chains (Jin 2008)
  • CELLULAR PROCESS cell cycle, division, mitosis
    cell cycle, progression
    protein, degradation
    protein, ubiquitin dependent proteolysis
    PHYSIOLOGICAL PROCESS
    text ubiquitin dependent catabolism
    PATHWAY
    metabolism
    signaling
    a component
  • component of the APC complex which is composed at least of eight subunits including ANAPC5, CDC27, CDC16, ANAPC7
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • binding the poly(A) binding protein (PABP)
  • interacting directly with the coactivators CBP and p300 through protein-protein interaction domains that are evolutionary donserved in adenovirus E1A
  • cell & other
    REGULATION
    Other degraded upon megakaryocytic differentiation in correlation with IRES activation
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS