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FLASH GENE

Symbol

ULBP2

contributors: mct - updated : 22-04-2013

HGNC name	UL16 binding protein 2
HGNC id	14894

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

PROTEIN

PHYSICAL PROPERTIES		globular
STRUCTURE

motifs/domains	glycosyl phosphatidylinositol (GPI) linkage to the membrane
	alpha 1 and alpha 2 domain

conjugated

GlycoP

HOMOLOGY

Homologene

FAMILY

MHC class I family

CATEGORY

receptor membrane

SUBCELLULAR LOCALIZATION	plasma membrane
text	glycosylphosphatidylinositol (GPI)-anchored

basic FUNCTION

enhancing NK cell-mediated target recognition

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component

INTERACTION

DNA

RNA

small molecule

protein	involvement of TP53 in the regulation of specific ULBP1, ULBP2, ULBP3 that enhance NK cell-mediated target recognition
	IGF2BP3 facilitates tumor immune escape by downregulating the stress-induced ligands ULBP2 and MICB

cell & other

REGULATION

activated by

RAS activation that upregulates the expression of ULBP1, ULBP2, ULBP3

Other

ULBP2 cell surface expression is controlled differently by calcium, which adds to the increasing perception that cell surface expression ULBP2 is controlled by distinct signal transduction pathways

ASSOCIATED DISORDERS

corresponding disease(s)

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function tumoral     --over   in ovarian cancer highly correlated with that of ULBP2, and high expression of ULBP2 is an indicator of poor prognosis in ovarian cancer and may relate to T cell dysfunction in the tumor microenvironment

Susceptibility

Variant & Polymorphism

Candidate gene
Marker	soluble ULBP2 seems to be useful to identify early-stage patients with risk of B-cell chronic lymphocytic leukemia progression
Therapy target

ANIMAL & CELL MODELS