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FLASH GENE
Symbol ULBP1 contributors: mct - updated : 28-11-2012
HGNC name UL16 binding protein 1
HGNC id 14893
PROTEIN
PHYSICAL PROPERTIES globular
STRUCTURE
motifs/domains
  • alpha 1 and alpha 2 domain
  • GPI domain
    • conjugated GlycoP
    HOMOLOGY
    intraspecies homolog to ulbp2
    homolog to ulbp3
    Homologene
    FAMILY
  • MHC class I family
    • CATEGORY receptor membrane
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm,organelle,membrane
    intracellular,cytoplasm,organelle,endoplasmic reticulum
    text glycosylphosphatidylinositol (GPI)-anchored
    basic FUNCTION
  • selective induction of ULBP1 expression by proteasome inhibitor drugs, along with variable KLRK1 ligand expression by human tumor cells, indicating that KLRK1 ligand genes are independently regulated
  • enhancing NK cell-mediated target recognition
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • target for the MARCH family of E3 ligases, MARCH4 and MARCH9, suggesting that induction of ULBP1 in response to heat shock is due to regulated association with its E3 ligases
  • GPI-linked ligand for natural cytotoxicity receptor KLRK1
  • involvement of TP53 in the regulation of specific ULBP1, ULBP2, ULBP3 that enhance NK cell-mediated target recognition
    • cell & other
    REGULATION
    activated by RAS activation that upregulates the expression of ULBP1, ULBP2, ULBP3
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    SystemTypeDisorderPubmed
    cancer  
    ULBP1 regulation may have implications for development of new therapeutic strategies against cancer cells
    ANIMAL & CELL MODELS