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FLASH GENE

Symbol

ULBP1

contributors: mct - updated : 28-11-2012

HGNC name	UL16 binding protein 1
HGNC id	14893

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

DNA

TYPE	functioning gene
STRUCTURE	9.70 kb     5 Exon(s)

10 Kb 5' upstream gene genomic sequence study

regulatory sequence	Promoter
	Binding site
text structure	ULBP1 promoter was inactive in the absence of the Sp proteins, indicating that Sp3 is the essential activator of ULBP1 transcription, because the overexpression of Sp3 up-regulated its promoter activity

MAPPING

cloned

Y

linked

N

status

provisional

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_025218 5 - 3160 NP_079494 27.8 244 - 2006 1690190

EXPRESSION

Type

expressed in	(based on citations)
organ(s)

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Blood / Hematopoietic         Lymphoid

cells

System Cell Pubmed Species Stage Rna symbol Lymphoid/Immune B cell

cell lineage
cell lines	erythroleukemia cell lines, tumor cell lines
fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES		globular
STRUCTURE

motifs/domains	alpha 1 and alpha 2 domain
	GPI domain

conjugated

GlycoP

HOMOLOGY

intraspecies	homolog to ulbp2
	homolog to ulbp3

Homologene

FAMILY

MHC class I family

CATEGORY

receptor membrane

SUBCELLULAR LOCALIZATION	plasma membrane
	intracellular
	intracellular,cytoplasm,organelle,membrane
	intracellular,cytoplasm,organelle,endoplasmic reticulum
text	glycosylphosphatidylinositol (GPI)-anchored

basic FUNCTION	selective induction of ULBP1 expression by proteasome inhibitor drugs, along with variable KLRK1 ligand expression by human tumor cells, indicating that KLRK1 ligand genes are independently regulated
	enhancing NK cell-mediated target recognition

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component

INTERACTION

DNA

RNA

small molecule

protein	target for the MARCH family of E3 ligases, MARCH4 and MARCH9, suggesting that induction of ULBP1 in response to heat shock is due to regulated association with its E3 ligases
	GPI-linked ligand for natural cytotoxicity receptor KLRK1
	involvement of TP53 in the regulation of specific ULBP1, ULBP2, ULBP3 that enhance NK cell-mediated target recognition

cell & other

REGULATION

activated by

RAS activation that upregulates the expression of ULBP1, ULBP2, ULBP3

ASSOCIATED DISORDERS

corresponding disease(s)

Susceptibility

Variant & Polymorphism

Candidate gene
Marker
Therapy target
	System Type Disorder Pubmed cancer     ULBP1 regulation may have implications for development of new therapeutic strategies against cancer cells

ANIMAL & CELL MODELS